產(chǎn)品概述
HDAC2 (2D9) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB,ICC/IF
Human,Mouse,Rat,Monkey
產(chǎn)品性能
Unconjugated
Unmodified
IgG2b
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
HDAC2
HDAC2; Histone deacetylase 2; HD2
3066
Q92769
產(chǎn)品應(yīng)用
WB: 1:500-1:1000 IF: 1:50-1:200
Calculated MW: 55 kDa; Observed MW: 60 kDa
研究背景
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA.
研究領(lǐng)域
Epigenetics and Nuclear Signaling
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