產(chǎn)品概述
DNA PKcs (8D3) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB,ICC/IF,IP
Human
產(chǎn)品性能
Unconjugated
Unmodified
IgG2b
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
PRKDC
PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460
5591
P78527
產(chǎn)品應(yīng)用
WB: 1:500-1:1000 IF: 1:50-1:200 IP: 1:20
Calculated MW: 469 kDa; Observed MW: 450 kDa
研究背景
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.
研究領(lǐng)域
Epigenetics and Nuclear Signaling
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