產(chǎn)品概述
QK1 Rabbit Monoclonal Antibody
Rabbit Monoclonal antibody
Rabbit
WB,IP
Human,Mouse,Rat
產(chǎn)品性能
Unconjugated
Unmodified
IgG
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Affinity Purification
免疫原
QKI
QK; Hqk; QK1; QK3; hqkI
9444
Q96PU8
產(chǎn)品應(yīng)用
WB: 1:500-1:1000 IP: 1:20
Calculated MW: 38 kDa; Observed MW: 38 kDa
研究背景
RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor .
研究領(lǐng)域
Neuroscience
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