產(chǎn)品概述
Phospho-ATF4 (Ser219) Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB
Human
產(chǎn)品性能
Unconjugated
Phosphorylated
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
ATF4
Cyclic AMP-dependent transcription factor ATF-4; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67
468
P18848
產(chǎn)品應(yīng)用
WB: 1:500-1:1000
Calculated MW: 39 kDa; Observed MW: 39 kDa
研究背景
ATF4, an activating transcription factor/cAMP-response element-binding protein family member, functions in the PERK and eIF2α ER stress responsive pathway. ER stress represses the translation of the majority of mRNAs, but selectively stimulates the translation of certain mRNAs including that of ATF-4. Induced expression of ATF-4 increases the expression of genes critical for the recovery from ER stress.
研究領(lǐng)域
Epigenetics and Nuclear Signaling
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