產(chǎn)品概述
Phospho-GSK3 (Tyr279/Tyr216) Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,IHC-P,ICC/IF
Human,Mouse,Rat
產(chǎn)品性能
Unconjugated
Phosphorylated
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
GSK3A
Serine/threonine-protein kinase GSK3A
2931
P49840
產(chǎn)品應(yīng)用
WB: 1:500-1:1000 IHC: 1:50-1:100 ICC: 1:100-1:200
Calculated MW: 51 kDa; Observed MW: 46,51 kDa
研究背景
GSK3A a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase.
研究領(lǐng)域
Neuroscience
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