產(chǎn)品概述
YAP (phospho Ser127) Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
IF-P,IF-F,ICC/IF,WB,IHC-P,ELISA
Human,Mouse,Rat,Monkey
產(chǎn)品性能
Unconjugated
Phospho Antibody
IgG
Polyclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Affinity purification
免疫原
YAP1
YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65
10413
P46937
產(chǎn)品應(yīng)用
IF-P/IF-F/ICC/IF 1:50-200, WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:40000.Not yet tested in other applications.
65kDa
研究背景
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,
研究領(lǐng)域
武漢恩璣生命科技有限公司
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