產(chǎn)品概述
| 產(chǎn)品名稱（Product Name） | ADAMTS-1 Rabbit Polyclonal Antibody |
| 描述（Description） | Rabbit Polyclonal Antibody |
| 宿主（Host） | Rabbit |
| 應用（Application） | WB,ELISA |
| 種屬反應性（Reactivity） | Human,Rat,Mouse |
產(chǎn)品性能
| 偶聯(lián)物（Conjugation） | Unconjugated |
| 修飾（Modification） | Unmodified |
| 同種型（Isotype） | IgG |
| 克隆（Clonality） | Polyclonal |
| 形式（Form） | Liquid |
| 存放說明（Storage） | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 儲存溶液（Buffer） | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| 純化方式（Purification） | Affinity purification |
免疫原
| 基因名（Gene Name） | ADAMTS1 |
| 別名（Alternative Names） | ADAMTS1; KIAA1346; METH1; A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1; METH-1 |
| 基因ID（Gene ID） | 9510 |
| 蛋白ID（SwissProt ID） | Q9UHI8 |
產(chǎn)品應用
| 稀釋比（Dilution Ratio） | WB 1:500-1:2000, ELISA 1:5000.Not yet tested in other applications. |
| 蛋白分子量（Molecular Weight） | 105kDa |
研究背景
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008],catalytic activity:Cleaves aggrecan at the 1938-Glu-|-Leu-1939 site, within the chondroitin sulfate attachment domain.,cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,function:Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 3 TSP type-1 domains.,
研究領域
關(guān)鍵字： ADAMTS1;ADAMTS-1;Rabbit;Polyclonal;Antibody;一抗
武漢恩璣生命科技有限公司（EnkiLife）是一家深耕生命科學，專注細胞生物學和免疫學科研試劑的研發(fā)、生產(chǎn)與銷售的生物技術(shù)企業(yè)，在全球100多個國家和地區(qū)開展業(yè)務，致力于為科研工作者提供高質(zhì)量的產(chǎn)品和卓越的客戶服務，推動生命科學的發(fā)展。
EnkiLife的產(chǎn)品線涵蓋細胞系、原代細胞、細胞培養(yǎng)基、血清、細胞檢測試劑盒、重組靶點蛋白、細胞因子、重組抗體、ELISA試劑盒、生化試劑盒等，并提供技術(shù)服務與定制開發(fā)，覆蓋了生命科學研究的各大關(guān)鍵領域，包括細胞生物學、癌癥、免疫學、神經(jīng)科學、心血管疾病、干細胞、表觀遺傳學、內(nèi)分泌、蛋白質(zhì)組學、代謝組學等，全方位滿足您的實驗需求，讓您享受科研的樂趣！
公司現(xiàn)已建立四大技術(shù)平臺：
EnCyto?細胞培養(yǎng)及檢測平臺：擁有細胞系庫（500+）、原代細胞庫（500+）、基礎培養(yǎng)基和完全培養(yǎng)基（1200+）
EnkiPro?重組蛋白平臺：現(xiàn)貨產(chǎn)品2000+，可提供定制化表達服務
EnAb?重組抗體平臺：重組兔單抗（3000+），可提供定制化和標記服務
EnKits?試劑盒開發(fā)平臺：可提供優(yōu)質(zhì)的ELISA試劑盒、配套試劑、抗體對、生化試劑盒等相關(guān)產(chǎn)品
EnkiLife在生產(chǎn)管理方面引入ISO9001質(zhì)量管理體系和信息化、自動化的管理工具，擁有高效穩(wěn)定的交付能力，與全球知名品牌建立了緊密的合作。
EnkiLife始終堅持以技術(shù)創(chuàng)新為驅(qū)動，以匠心鑄就品質(zhì)，以品質(zhì)服務客戶。
我們期待與更多的全球科研工作者和企業(yè)攜手合作，共同推動生命科學領域的進步與發(fā)展。