Biotinylated Human IL-17A&IL-17F Protein, Avitag?,His Tag
分子別名(Synonym)
IL-17A, Interleukin-17A, CTLA-8, IL-17, IL-17F, Interleukin-17F, Cytokine ML-1, IL17A&IL17F
表達區(qū)間及表達系統(tǒng)(Source)
Biotinylated Human IL-17A&IL-17F, Avitag,His Tag (ILF-H82W1) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (IL-17A) & Arg 31 - Gln 163 (IL-17F) (Accession # Q16552-1 (IL-17A) & Q96PD4-1 (IL-17F)).
Predicted N-terminus: Gly 24
蛋白結構(Molecular Characterization)

Subunit IL-17A&IL-17F is fused with an Avi tag (Avitag?) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 34.1 kDa. The protein migrates as 40-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
標記(Labeling)
Biotinylation of this product is performed using Avitag? technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
蛋白標記度(Protein Ratio)
Passed as determined by the HABA assay / binding ELISA.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景介紹
白細胞介素17A(IL17A)亦稱為細胞毒性T淋巴細胞相關抗原8(CTLA8),是一種由活化T細胞產生的促炎細胞因子。該因子能夠調控NF-κB與絲裂原活化蛋白激酶(MAPK)的活性,同時可刺激IL6和環(huán)氧化酶-2(PTGS2/COX-2)的表達,并促進一氧化氮(NO)的生成。此外,研究發(fā)現(xiàn)IL17A存在糖基化和非糖基化兩種形式。該因子高水平表達與多種慢性炎癥性疾病相關,包括類風濕關節(jié)炎、銀屑病及多發(fā)性硬化癥。
關鍵字: IL-17A&IL-17F;IL-17A蛋白;IL-17F重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。