Biotinylated Human DR3 / TNFRSF25 Protein, His,Avitag? (MALS verified)
分子別名（Synonym）
TNFRSF25,DR3,APO3,DDR3,TNFRSF12,WSL,WSL1
表達區(qū)間及表達系統(tǒng)（Source）
Biotinylated Human DR3 Protein, His,Avitag (DR3-H82E3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Gln 199 (Accession # Q93038-1).
蛋白結構（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?).
The protein has a calculated MW of 22.6 kDa. The protein migrates as 30-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
標記（Labeling）
Biotinylation of this product is performed using Avitag? technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
蛋白標記度（Protein Ratio）
Passed as determined by the HABA assay / binding ELISA.
純度（Purity）
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景介紹
腫瘤壞死因子受體超家族成員25（TNFRSF25）亦稱Apo-3、死亡受體3（DDR3或DR3）、凋亡誘導受體AIR、凋亡介導受體TRAMP、淋巴細胞相關死亡受體，是TNF受體超家族的重要成員。該蛋白為同源二聚體結構，能通過死亡結構域與TNFRSF1及TRADD發(fā)生強相互作用，進而激活至少兩條不同的信號通路——細胞凋亡通路與NF-κB信號通路。TNFRSF25是TNFSF12/APO3L/TWEAK的特定受體。
關鍵字： DR3;DR3蛋白;DR3重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下擁有品牌ACROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。