Product Name：Cyclic(YCDGFYACYMDV)
CAS No.：535959-77-4
Synonyms：信號傳導(dǎo)抑制劑多肽Cyclic(YCDGFYACYMDV)
Catalog No.：220P309
Brand：Typeptide Biotech（肽研生物）
Description：Cyclic(YCDGFYACYMDV)是一種 HER2 信號傳導(dǎo)抑制劑多肽，是由12個(gè)氨基酸組成的多肽，具有抗癌活性。Cyclic(YCDGFYACYMDV) 在水溶液中自組裝成納米顆粒，通過與癌細(xì)胞上的 HER2 靶向結(jié)合轉(zhuǎn)化為納米原纖維，來破壞 HER2 二聚化和隨后的下游信號事件，從而導(dǎo)致癌細(xì)胞凋亡 (Apoptosis)。這種對 HER2 乳腺癌的抑制作用在小鼠異種移植模型中被證明有效。
Cyclic(YCDGFYACYMDV) is a HER2 signaling inhibitor peptide composed of 12 amino acids, exhibiting anticancer activity. In aqueous solution, Cyclic(YCDGFYACYMDV) self-assembles into nanoparticles, which target and bind to HER2 on cancer cells, transforming into nanofibrils. This disrupts HER2 dimerization and subsequent downstream signaling events, ultimately inducing apoptosis (programmed cell death) in cancer cells. This HER2 breast cancer inhibitory effect has been validated in mouse xenograft models.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | YCDGFYACYMDV(Disulfide bridge: Cys2-Cys8) |
Sequence(3-letter code) | H-Tyr-Cys-Asp-Gly-Phe-Tyr-Ala-Cys-Tyr-Met-Asp-Val-OH(Disulfide bridge: Cys2-Cys8) |
Peptide Structure | 
|
Molecular Formula | C65H82N12O20S3 |
Molecular Weight | 1447.61 |
訂購聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號：19961912513(微信同號)
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： Cyclic(YCDGFYACYMDV);535959-77-4;信號傳導(dǎo)抑制劑多肽Cyclic(YCDG;多肽;多肽合成;
肽研生物坐落于國家級新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。