產(chǎn)品概述
| 產(chǎn)品名稱(Product Name) | Caveolin-1 Rabbit Polyclonal Antibody |
| 描述(Description) | Rabbit Polyclonal Antibody |
| 宿主(Host) | Rabbit |
| 應(yīng)用(Application) | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| 種屬反應(yīng)性(Reactivity) | Human,Mouse,Rat |
產(chǎn)品性能
| 偶聯(lián)物(Conjugation) | Unconjugated |
| 修飾(Modification) | Unmodified |
| 同種型(Isotype) | IgG |
| 克隆(Clonality) | Polyclonal |
| 形式(Form) | Liquid |
| 存放說明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 儲(chǔ)存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| 純化方式(Purification) | Affinity purification |
免疫原
| 基因名(Gene Name) | CAV1 |
| 別名(Alternative Names) | CAV1; CAV; Caveolin-1 |
| 基因ID(Gene ID) | 857 |
| 蛋白ID(SwissProt ID) | Q03135 |
產(chǎn)品應(yīng)用
| 稀釋比(Dilution Ratio) | WB 1:500-2000, IF-P/IF-F/ICC/IF 1:50-300, IHC-P 1:50-300 |
| 蛋白分子量(Molecular Weight) | 25kDa |
研究背景
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010],disease:Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.,function:May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.,online information:Caveolin entry,PTM:The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.,similarity:Belongs to the caveolin family.,subcellular location:Potential hairpin-like structure in the membrane. Membrane protein of caveolae.,subunit:Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4.,tissue specificity:In muscle and lung, less so in liver, brain and kidney.,
研究領(lǐng)域
Focal adhesion;Viral myocarditis;
關(guān)鍵字: CAV1;Caveolin-1;Rabbit;Polyclonal;Antibody;一抗
武漢恩璣生命科技有限公司(EnkiLife)是一家深耕生命科學(xué),專注細(xì)胞生物學(xué)和免疫學(xué)科研試劑的研發(fā)、生產(chǎn)與銷售的生物技術(shù)企業(yè),在全球100多個(gè)國(guó)家和地區(qū)開展業(yè)務(wù),致力于為科研工作者提供高質(zhì)量的產(chǎn)品和卓越的客戶服務(wù),推動(dòng)生命科學(xué)的發(fā)展。
EnkiLife的產(chǎn)品線涵蓋細(xì)胞系、原代細(xì)胞、細(xì)胞培養(yǎng)基、血清、細(xì)胞檢測(cè)試劑盒、重組靶點(diǎn)蛋白、細(xì)胞因子、重組抗體、ELISA試劑盒、生化試劑盒等,并提供技術(shù)服務(wù)與定制開發(fā),覆蓋了生命科學(xué)研究的各大關(guān)鍵領(lǐng)域,包括細(xì)胞生物學(xué)、癌癥、免疫學(xué)、神經(jīng)科學(xué)、心血管疾病、干細(xì)胞、表觀遺傳學(xué)、內(nèi)分泌、蛋白質(zhì)組學(xué)、代謝組學(xué)等,全方位滿足您的實(shí)驗(yàn)需求,讓您享受科研的樂趣!
公司現(xiàn)已建立四大技術(shù)平臺(tái):
EnCyto?細(xì)胞培養(yǎng)及檢測(cè)平臺(tái):擁有細(xì)胞系庫(kù)(500+)、原代細(xì)胞庫(kù)(500+)、基礎(chǔ)培養(yǎng)基和完全培養(yǎng)基(1200+)
EnkiPro?重組蛋白平臺(tái):現(xiàn)貨產(chǎn)品2000+,可提供定制化表達(dá)服務(wù)
EnAb?重組抗體平臺(tái):重組兔單抗(3000+),可提供定制化和標(biāo)記服務(wù)
EnKits?試劑盒開發(fā)平臺(tái):可提供優(yōu)質(zhì)的ELISA試劑盒、配套試劑、抗體對(duì)、生化試劑盒等相關(guān)產(chǎn)品
EnkiLife在生產(chǎn)管理方面引入ISO9001質(zhì)量管理體系和信息化、自動(dòng)化的管理工具,擁有高效穩(wěn)定的交付能力,與全球知名品牌建立了緊密的合作。
EnkiLife始終堅(jiān)持以技術(shù)創(chuàng)新為驅(qū)動(dòng),以匠心鑄就品質(zhì),以品質(zhì)服務(wù)客戶。
我們期待與更多的全球科研工作者和企業(yè)攜手合作,共同推動(dòng)生命科學(xué)領(lǐng)域的進(jìn)步與發(fā)展。