產(chǎn)品概述
| 產(chǎn)品名稱(chēng)(Product Name) | Cleaved-Caspase-2 p18 (T325) Rabbit Polyclonal Antibody |
| 描述(Description) | Rabbit Polyclonal Antibody |
| 宿主(Host) | Rabbit |
| 應(yīng)用(Application) | WB,ELISA |
| 種屬反應(yīng)性(Reactivity) | Human,Mouse,Rat |
產(chǎn)品性能
| 偶聯(lián)物(Conjugation) | Unconjugated |
| 修飾(Modification) | Unmodified |
| 同種型(Isotype) | IgG |
| 克隆(Clonality) | Polyclonal |
| 形式(Form) | Liquid |
| 存放說(shuō)明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 儲(chǔ)存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| 純化方式(Purification) | Affinity purification |
免疫原
| 基因名(Gene Name) | CASP2 |
| 別名(Alternative Names) | CASP2; ICH1; NEDD2; Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1 |
| 基因ID(Gene ID) | 835 |
| 蛋白ID(SwissProt ID) | P42575 |
產(chǎn)品應(yīng)用
| 稀釋比(Dilution Ratio) | WB 1:500-1:2000, ELISA 1:10000.Not yet tested in other applications. |
| 蛋白分子量(Molecular Weight) | 22kDa |
研究背景
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],alternative products:Isoforms differ in the N- and C-termini,catalytic activity:Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.,PTM:The mature protease can process its own propeptide, but not that of other caspases.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.,tissue specificity:Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.,
研究領(lǐng)域
關(guān)鍵字: CASP2;Cleaved-Caspase-2;p18;(T325);Rabbit;Polyclonal;Antibody;一抗
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