產(chǎn)品概述
| 產(chǎn)品名稱(Product Name) | Integrin αV Rabbit Polyclonal Antibody |
| 描述(Description) | Rabbit Polyclonal Antibody |
| 宿主(Host) | Rabbit |
| 應(yīng)用(Application) | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| 種屬反應(yīng)性(Reactivity) | Human,Mouse |
產(chǎn)品性能
| 偶聯(lián)物(Conjugation) | Unconjugated |
| 修飾(Modification) | Unmodified |
| 同種型(Isotype) | IgG |
| 克?。–lonality) | Polyclonal |
| 形式(Form) | Liquid |
| 存放說明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 儲(chǔ)存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| 純化方式(Purification) | Affinity purification |
免疫原
| 基因名(Gene Name) | ITGAV |
| 別名(Alternative Names) | ITGAV; MSK8; VNRA; Integrin alpha-V; Vitronectin receptor subunit alpha; CD antigen CD51 |
| 基因ID(Gene ID) | 3685 |
| 蛋白ID(SwissProt ID) | P06756 |
產(chǎn)品應(yīng)用
| 稀釋比(Dilution Ratio) | WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:20000, IF-P/IF-F/ICC/IF 1:50-200 |
| 蛋白分子量(Molecular Weight) | 135kDa |
研究背景
integrin subunit alpha V(ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],function:The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.,
研究領(lǐng)域
Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Regulates Actin and Cytoskeleton;Pathways in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
關(guān)鍵字: ITGAV;Integrin;αV;Rabbit;Polyclonal;Antibody;一抗
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