產(chǎn)品概述
| 產(chǎn)品名稱（Product Name） | P-glycoprotein 1 Rabbit Polyclonal Antibody |
| 描述（Description） | Rabbit Polyclonal Antibody |
| 宿主（Host） | Rabbit |
| 應(yīng)用（Application） | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| 種屬反應(yīng)性（Reactivity） | Human,Mouse,Rat |
產(chǎn)品性能
| 偶聯(lián)物（Conjugation） | Unconjugated |
| 修飾（Modification） | Unmodified |
| 同種型（Isotype） | IgG |
| 克隆（Clonality） | Polyclonal |
| 形式（Form） | Liquid |
| 存放說明（Storage） | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 儲(chǔ)存溶液（Buffer） | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| 純化方式（Purification） | Affinity purification |
免疫原
| 基因名（Gene Name） | ABCB1 |
| 別名（Alternative Names） | p-pg;ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243 |
| 基因ID（Gene ID） | 5243 |
| 蛋白ID（SwissProt ID） | P08183 |
產(chǎn)品應(yīng)用
| 稀釋比（Dilution Ratio） | WB 1:500-2000, IHC-P 1:100-1:300, ELISA 1:40000, IF-P/IF-F/ICC/IF 1:50-200 |
| 蛋白分子量（Molecular Weight） | |
研究背景
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008],catalytic activity:ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).,disease:Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.,function:Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.,online information:P-glycoprotein entry,online information:The Singapore human mutation and polymorphism database,polymorphism:Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Expressed in liver, kidney, small intestine and brain.,
研究領(lǐng)域
ABC transporters;
關(guān)鍵字： ABCB1;P-glycoprotein;1;Rabbit;Polyclonal;Antibody;一抗
武漢恩璣生命科技有限公司（EnkiLife）是一家深耕生命科學(xué)，專注細(xì)胞生物學(xué)和免疫學(xué)科研試劑的研發(fā)、生產(chǎn)與銷售的生物技術(shù)企業(yè)，在全球100多個(gè)國家和地區(qū)開展業(yè)務(wù)，致力于為科研工作者提供高質(zhì)量的產(chǎn)品和卓越的客戶服務(wù)，推動(dòng)生命科學(xué)的發(fā)展。
EnkiLife的產(chǎn)品線涵蓋細(xì)胞系、原代細(xì)胞、細(xì)胞培養(yǎng)基、血清、細(xì)胞檢測試劑盒、重組靶點(diǎn)蛋白、細(xì)胞因子、重組抗體、ELISA試劑盒、生化試劑盒等，并提供技術(shù)服務(wù)與定制開發(fā)，覆蓋了生命科學(xué)研究的各大關(guān)鍵領(lǐng)域，包括細(xì)胞生物學(xué)、癌癥、免疫學(xué)、神經(jīng)科學(xué)、心血管疾病、干細(xì)胞、表觀遺傳學(xué)、內(nèi)分泌、蛋白質(zhì)組學(xué)、代謝組學(xué)等，全方位滿足您的實(shí)驗(yàn)需求，讓您享受科研的樂趣！
公司現(xiàn)已建立四大技術(shù)平臺(tái)：
EnCyto?細(xì)胞培養(yǎng)及檢測平臺(tái)：擁有細(xì)胞系庫（500+）、原代細(xì)胞庫（500+）、基礎(chǔ)培養(yǎng)基和完全培養(yǎng)基（1200+）
EnkiPro?重組蛋白平臺(tái)：現(xiàn)貨產(chǎn)品2000+，可提供定制化表達(dá)服務(wù)
EnAb?重組抗體平臺(tái)：重組兔單抗（3000+），可提供定制化和標(biāo)記服務(wù)
EnKits?試劑盒開發(fā)平臺(tái)：可提供優(yōu)質(zhì)的ELISA試劑盒、配套試劑、抗體對(duì)、生化試劑盒等相關(guān)產(chǎn)品
EnkiLife在生產(chǎn)管理方面引入ISO9001質(zhì)量管理體系和信息化、自動(dòng)化的管理工具，擁有高效穩(wěn)定的交付能力，與全球知名品牌建立了緊密的合作。
EnkiLife始終堅(jiān)持以技術(shù)創(chuàng)新為驅(qū)動(dòng)，以匠心鑄就品質(zhì)，以品質(zhì)服務(wù)客戶。
我們期待與更多的全球科研工作者和企業(yè)攜手合作，共同推動(dòng)生命科學(xué)領(lǐng)域的進(jìn)步與發(fā)展。