Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
分子別名（Synonym）
IL7Ra, CD127, TSLP R, CRLF2, IL-XR, ILXR, p2RY8, CRLF2 fusion, TSLP receptor, TSLPR, CRL2, CRLF2Y, Cytokine receptor-like 2
表達區(qū)間及表達系統(tǒng)（Source）
Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (ILR-H5255) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Asp 239 (IL-7 RA) & Gln 23 - Lys 231 (TSLP R) (Accession # P16871-1 (I66T, V138I) (IL-7RA) & Q9HC73-1 (TSLPR)).
Predicted N-terminus: Glu 21 (IL-7 RA) & Gln 23 (TSLP R)
蛋白結構（Molecular Characterization）
Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of IL-7 RA and TSLP R, has a calculated MW of 51.7 kDa (IL-7 RA) and 50.3 kDa (TSLP R). Subunit IL-7 RA is fused with a human IgG1 Fc fragment at the C-terminus and subunit TSLP R is fused with a human IgG1 Fc fragment at the C-terminus. The reducing (R) protein migrates as 60-80 kDa due to glycosylation.
內毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method / rFC method.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景介紹
胸腺基質淋巴細胞生成素（TSLP）是一種多效性細胞因子，最初被鑒定為淋巴細胞生長因子。該因子在重癥哮喘患者氣道中呈高表達，是協(xié)同調節(jié)哮喘炎癥反應的上游細胞因子。人源TSLP通過結合由TSLPR與IL-7受體組成的高親和力異源二聚體受體復合物發(fā)揮生物活性，并在共表達TSLPR與IL-7R的細胞中啟動信號傳導。
關鍵字： IL7Ra&TSLP R;IL7Ra蛋白;TSLP R重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。