4-溴-3-氟甲苯

英文名稱：4-Bromo-3-fluorotoluene，又名3-氟-4-溴甲苯，是一種分子式為C7H6BrF的有機(jī)化合物，CAS號(hào)為452-74-4，分子量189.02500。常溫下為無色至淡黃色液體，密度1.494 g/mL（25℃），沸點(diǎn)95℃（50mmHg），閃點(diǎn)95℉，折射率n20/D 1.53

具體用途

該化合物作為有機(jī)合成中間體，通過重氮化溴代、Schiemann反應(yīng)等步驟參與藥物合成路徑，最終用于生產(chǎn)曲格列汀這類糖尿病治療藥物。其合成路線涉及高溫重氮化工藝，可提升生產(chǎn)效率并降低能耗。 ?

物理性質(zhì)

4-溴-3-氟甲苯為無色透明液體，常溫下具有刺激性氣味，沸點(diǎn)95℃（50mmHg），密度1.494g/mL（25℃），純度通常≥98%。

4-Bromo-3-fluorotoluene

English Name: 4-Bromo-3-fluorotoluene, also known as 3-Fluoro-4-bromotoluene, is an organic compound with the molecular formula C?H?BrF. Its CAS number is 452-74-4, and its molecular weight is 189.02500. At room temperature, it appears as a colorless to pale yellow liquid, with a density of 1.494 g/mL (at 25°C), a boiling point of 95°C (at 50 mmHg), a flash point of 95°F, and a refractive index of n20/D 1.53.

Specific Applications

This compound serves as an organic synthesis intermediate. It participates in pharmaceutical synthesis pathways through steps such as diazotization bromination and the Schiemann reaction, ultimately used in the production of antidiabetic drugs like Trelegliptin. The synthetic route involves a high-temperature diazotization process, which enhances production efficiency and reduces energy consumption.

Physical Properties

4-Bromo-3-fluorotoluene is a colorless, transparent liquid with a pungent odor at room temperature. It has a boiling point of 95°C (at 50 mmHg), a density of 1.494 g/mL (at 25°C), and a purity typically ≥98%.