Product Name：Amylin,amide,human acetate
CAS No.：122384-88-7
Synonyms：糖尿病相關(guān)肽(胰島淀粉樣肽)
Catalog No.：106P01
Brand：Typeptide Biotech（肽研生物）
Description：Amylin,amide,human acetate是一種37個(gè)氨基酸的多肽，是一種與胰島素共分泌的胰腺激素，在代謝和葡萄糖穩(wěn)態(tài)中發(fā)揮獨(dú)特的作用。能抑制胰高血糖素分泌，延遲胃排空，并作為飽腹劑。MCF-7 細(xì)胞內(nèi)源性表達(dá)人胰淀素受體 CTR1 和 CTR2。 用胰淀素、酰胺、人刺激受體導(dǎo)致產(chǎn)生 cAMP。 Amylin, amide, human (0.001 nM-1000 μM) 導(dǎo)致 EC50 為 35.2±7.5 nM。通過(guò)皮下途徑注射到不同的瑞士雄性小鼠組中。 觀察到游離胰淀素的典型 PK 曲線，半衰期為 23 分鐘。
Amylin, amide, human acetate is a 37-amino acid polypeptide, a pancreatic hormone co-secreted with insulin, which plays a unique role in metabolism and glucose homeostasis. It inhibits glucagon secretion, delays gastric emptying, and functions as a satiety agent. MCF-7 cells endogenously express human amylin receptors CTR1 and CTR2. Stimulation of these receptors with amylin, amide, human leads to the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) resulted in an EC50 of 35.2±7.5 nM. It was administered subcutaneously to different groups of Swiss male mice. A typical PK curve of free amylin was observed, with a half-life of 23 minutes.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2(Disulfide bridge：Cys2-Cys7) |
Sequence(3-letter code) | H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bond：Cys2-Cys7) |
Peptide Structure | 
|
Molecular Formula | C165H261N51O55S2 |
Molecular Weight | 3903.32 |
訂購(gòu)聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： Amylin,amide,human a;糖尿病相關(guān)肽(胰島淀粉樣肽);122384-88-7;多肽;多肽合成;
肽研生物坐落于國(guó)家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷(xiāo)售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠(chéng)信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。