Biotinylated Human IL-2 R beta / CD122 Protein, His,Avitag?
分子別名（Synonym）
IL2RB,RP5-1170K4.6,CD122,P70-75
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
Biotinylated Human IL-2 R beta, His,Avitag (ILB-H82E3) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Asp 239 (Accession # P14784-1).
Predicted N-terminus: Ala 27
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?).
The
protein has a calculated MW of 28.2 kDa. The protein migrates as 35-38
kDa and 42-45 kDa under reducing (R) condition (SDS-PAGE) due to
glycosylation.
標(biāo)記（Labeling）
Biotinylation
of this product is performed using Avitag? technology. Briefly, the
single lysine residue in the Avitag is enzymatically labeled with
biotin.
蛋白標(biāo)記度（Protein Ratio）
Passed as determined by the HABA assay / binding ELISA.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景介紹
Interleukin-2
receptor (IL-2R) is a heterotrimeric protein expressed on the surface
of certain immune cells, such as lymphocytes, that binds and responds to
a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β
(CD122) and γ (CD132) - non-covalently associating. The α and β chains
are involved in binding IL-2, while signal transduction following
cytokine interaction is carried out by the γ-chain, along with the β
subunit.
CD122
is also known as IL2R beta, is a member of the type I cytokine receptor
family. CD122 is the receptor for interleukin-2 and is involved in
receptor mediated endocytosis and transduces the mitogenic signals of
IL2.
關(guān)鍵字： IL2RB;IL2RB蛋白;IL2RB重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國(guó)生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。