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SOCS-1 抗體
品牌：MedChemExpress (MCE)
貨號(hào)：HY-P85715
存儲(chǔ)條件：-20°C保存1年。避免重復(fù)凍結(jié)/解凍循環(huán)。
運(yùn)輸條件：用藍(lán)冰運(yùn)輸。
產(chǎn)品活性：SOCS-1 Antibody (YA5407) 是一種小鼠來(lái)源、無(wú)偶聯(lián)標(biāo)記、抗 SOCS-1 的單克隆抗體。它可用于人、小鼠、大鼠背景下的 IHC-P、WB 實(shí)驗(yàn)。
研究背景：SOCS-1 是 I 型和 II 型干擾素 (IFN) 信號(hào)通路以及其他細(xì)胞因子 (包括 IL2、IL4、IL6 和白血病抑制因子 (LIF)) 的關(guān)鍵負(fù)調(diào)控因子。它通過(guò)抑制 JAK/STAT 信號(hào)通路來(lái)下調(diào)細(xì)胞因子信號(hào)傳導(dǎo)，具體機(jī)制是與 JAK 蛋白和 IFNGR1 結(jié)合并抑制其激酶活性。在體外實(shí)驗(yàn)中，SOCS-1 還能抑制 Tec 蛋白酪氨酸活性。此外，它可能作為 ECS (Elongin BC-CUL2/5-SOCS-box 蛋白) E3 泛素連接酶復(fù)合物的底物識(shí)別組分，介導(dǎo)靶蛋白的泛素化和隨后的蛋白酶體降解。根據(jù)相似性研究，SOCS-1 還參與調(diào)節(jié) IFN-gamma (IFNG) 介導(dǎo)的感覺(jué)神經(jīng)元存活。
宿主：Mouse
反應(yīng)物種：Human, Mouse, Rat
推薦稀釋比例：IHC1:50-200; WB: 1:1000-2000 Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using SOCS-1 Antibody. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked in QuickBlock for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody at 1/100 dilution in 4℃ overnight. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using SOCS-1 Antibody. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked in QuickBlock for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody at 1/100 dilution in 4℃ overnight. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.
基因 ID：8651
同用名：Suppressor of cytokine signaling 1; SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3;
克隆性：Monoclonal
偶聯(lián)：Non-conjugated
修飾：Unmodified
蛋白數(shù)據(jù)庫(kù)：O15524
詳情參考：www.medchemexpress.cn/antibody/socs-1-antibody-ya5407.html