Product Name：Fz7-21
CAS No.：2247635-23-8
Synonyms：拮抗劑多肽Fz7-21
Catalog No.：218P101
Brand：Typeptide Biotech（肽研生物）
Description：Fz7-21是一種FZD7（FZD7）受體的肽拮抗劑，由14個(gè)氨基酸組成，肽鏈的兩端均被封閉，選擇性地與FZD7-CRD亞類結(jié)合。人和小鼠FZD7-CRD的EC50值分別為58和34nm。Fz7-21在外源性WNT3A（IC50=100?nM）刺激或轉(zhuǎn)染表達(dá)WNT3A或WNT1的HEK293細(xì)胞中削弱Wnt/β-catenin信號(hào)傳導(dǎo)。小鼠β2 1-3nM細(xì)胞的穩(wěn)定化作用。
Fz7-21 is a peptide antagonist of the FZD7 receptor, composed of 14 amino acids with both ends of the peptide chain blocked. It selectively binds to the FZD7-CRD subclass, with EC50 values of 58 nM and 34 nM for human and mouse FZD7-CRD, respectively. Fz7-21 inhibits Wnt/β-catenin signaling in HEK293 cells stimulated by exogenous WNT3A (IC50=100 nM) or transfected to express WNT3A or WNT1. It also stabilizes β-catenin in mouse cells at 1-3 nM concentrations.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-LPSDDLEFWCHVMY-NH2 |
Sequence(3-letter code) | Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2 |
Peptide Structure | 
|
Molecular Formula | C83H114N18O23S2 |
Molecular Weight | 1796.04 |
訂購(gòu)聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： Fz7-21;拮抗劑多肽Fz7-21;2247635-23-8;多肽;多肽合成;
肽研生物坐落于國(guó)家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠(chéng)信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。