Trypacidin 是具有抗原蟲(chóng)活性的分生孢子結(jié)合的代謝產(chǎn)物。Trypacidin 對(duì)環(huán)境中和感染過(guò)程中的吞噬細(xì)胞都有保護(hù)功能。Trypacidin is a fungal metabolite originally isolated from A. fumigatus.1 It is active against B. subtilis and M. bovis (MICs = 12.5 and 1.25 μg/ml, respectively), as well as T. cruzi and T. gondii (MICs = 5-10 and 10-20 μg/ml, respectively).1,2 It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3 Trypacidin increases survival in a mouse model of T. gondii infection when administered in six doses of 12.5 mg/kg each.1