Product Name：FOXO4-DRI
CAS No.：2460055-10-9
Synonyms：抗衰肽fox04-DRI
Catalog No.：218P009
Brand：Typeptide Biotech（肽研生物）
Description：FOXO4是促進(jìn)衰老細(xì)胞存活的重要分子，是由44個(gè)氨基酸組成的多肽。FOXO4可以與蛋白質(zhì)p53（一種已知的衰老誘導(dǎo)蛋白）相互作用。研究人員推斷，這種FOXO4-p53相互作用對(duì)于衰老細(xì)胞的存活可能是至關(guān)重要的，并且破壞這種相互作用將推動(dòng)細(xì)胞凋亡。為了測(cè)試這一點(diǎn)，他們合成了被稱為FOXO4-D逆轉(zhuǎn)錄（FOXO4-DRI）的修飾肽片段。這種肽片段缺乏FOXO4的正常轉(zhuǎn)錄活性，但是與p53的結(jié)合更穩(wěn)定，因此可以競(jìng)爭(zhēng)性地抑制FOXO4-p53相互作用。
FOXO4 is a key molecule that promotes the survival of senescent cells, consisting of a 44-amino-acid polypeptide. FOXO4 can interact with the protein p53, a well-known senescence-inducing protein. Researchers inferred that this FOXO4-p53 interaction is crucial for the survival of senescent cells, and disrupting this interaction would induce apoptosis. To test this, they synthesized a modified peptide fragment called FOXO4-D reversal (FOXO4-DRI). This peptide fragment lacks the normal transcriptional activity of FOXO4 but binds more stably to p53, thereby competitively inhibiting the FOXO4-p53 interaction.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | ltlrkepaseiaqsileaysqngwanrrsggkrppprrrqrrkkrg(all D-AA, D型Ile用D-ALLO-Ile) |
Sequence(3-letter code) | H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-Gly-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-Gly-OH（D-Ile in the sequence is D-allo-Ile） |
Peptide Structure |  
|
Molecular Formula | C228H388N86O64 |
Molecular Weight | 5358.06 |
訂購(gòu)聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： FOXO4-DRI;抗衰肽fox04-DRI;2460055-10-9;多肽;多肽合成;
肽研生物坐落于國(guó)家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠(chéng)信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。