生物活性Surfactin是一種環(huán)狀脂肽生物表面活性劑，可介導(dǎo)單價和二價陽離子(如鈣離子)穿過脂質(zhì)雙層膜的通量。Surfactin可以作為抗微生物佐劑，具有抗菌，抗真菌，抗支原體和溶血作用。Surfactin還對多種包膜病毒具有抗病毒活性。靶點(diǎn)HSV-1HSV-2體外研究SurfactincanincreasetheactivityofNSC277174againstavianpathogenicEscherichiacoli(APEC)invitrowithantimicrobialassayssuchasminimuminhibitoryconcentrations(MIC)andfractionalinhibitoryconcentration(FIC).ForAPECO78strain,theMICofNSC277174andSurfactinare1000ug/mland>1mg/ml,respectively.體內(nèi)研究Inthemodelofchickinfection(inoculationofE.coli),SurfactinexertsadjuvanteffectswithNSC277174againstAPECbyloweringthenumericalvalueofmortalityandliverbacterialloads,andregulatingtheexpressionofinflammatorycytokinesetal.SurfactincanactasanovelantimicrobialadjuvantwithNSC277174againstAEPCinfectioninchicken.