Product Name：Ras Inhibitory Peptide
CAS No.：159088-48-9
Synonyms：Ras抑制肽
Catalog No.：218P185
Brand：Typeptide Biotech（肽研生物）
Description：Ras Inhibitory Peptide是一種抑制劑多肽，是由10個(gè)氨基酸支持的直鏈多肽。Son of Sevenless 同源物 1 (Sos1) 是一種鳥(niǎo)嘌呤核苷酸交換因子 (GEF)，通過(guò)與生長(zhǎng)因子受體結(jié)合蛋白 2 (Grb2) 的 SH3 結(jié)構(gòu)域結(jié)合，指導(dǎo) Ras-GDP 與 Ras-GTP 的交換，從而導(dǎo)致 ERK 的激活。Ras 抑制肽是包含序列 PVPPR 的合成肽，該序列對(duì)應(yīng)于人類 Sos1 中與 Grb2 的 SH3 結(jié)構(gòu)域相互作用的區(qū)域，專門阻斷 GEF 與 Grb2 的相互作用，防止受體酪氨酸激酶（包括表皮生長(zhǎng)因子受體）激活 Ras 所必需的相互作用。
Ras Prohibitive Peptide is an inhibitor peptide that is a straight chain peptide supported by 10 amino acids. Son of Sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that guides the exchange of Ras GDP and Ras GTP by binding to the SH3 domain of growth factor receptor binding protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide containing the sequence PVPRR, which corresponds to the region in human Sos1 that interacts with the SH3 domain of Grb2. It specifically blocks the interaction between GEF and Grb2, preventing the necessary interaction for receptor tyrosine kinases (including epidermal growth factor receptors) to activate Ras.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | VPPPVPPRRR |
Sequence(3-letter code) | H-Val-Pro-Pro-Pro-Val-Pro-Pro-Arg-Arg-Arg-OH |
Peptide Structure | 
|
Molecular Formula | C53H91N19O11 |
Molecular Weight | 1170.43 |
訂購(gòu)聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： Ras Inhibitory Pepti;Ras抑制肽;159088-48-9;多肽;多肽合成;
肽研生物坐落于國(guó)家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠(chéng)信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。