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曲前列尼爾鈉,Treprostinil Sodium
  • 曲前列尼爾鈉,Treprostinil Sodium

曲前列尼爾鈉|T5171|TargetMol

價格 ￥455 ￥892 ￥1360
包裝 1mg 5mg 10mg
最小起訂量 1mg
發(fā)貨地 上海
更新日期 2026-05-08
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產(chǎn)品詳情

中文名稱:曲前列尼爾鈉英文名稱:Treprostinil Sodium
CAS:289480-64-4品牌: TargetMol
產(chǎn)地: 美國保存條件: Store at low temperature,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
純度規(guī)格: 99.67%產(chǎn)品類別: 抑制劑
貨號: T001|T5171
2026-05-08 曲前列尼爾鈉 Treprostinil Sodium 1mg/455RMB;5mg/892RMB;10mg/1360RMB 455 TargetMol 美國 Store at low temperature,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 99.67% 抑制劑

Product Introduction

Bioactivity

名稱Treprostinil Sodium
描述Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
細胞實驗Immunohistochemistry was used to determine vessel density by analyzing the expression of CD31, an endothelial marker. Briefly, nude mice xenografted with NCI-H460 tumor were treated with 200 mg/kg Apatinib by the oral garage for 14 days and tumor sections were prepared from formalin-fixed and paraffin-embedded tumor tissues. Slides were treated with 3% H2O2 for 10 min and then incubated in 2% goat serum for 20 min to block the nonspecific antibody binding. Slides were stained with the anti-CD31 antibody at room temperature for 2 h, followed by treatment with biotinylated goat anti-mouse IgG and SABC complex at 37C for 30 min. Finally, diaminobenzidine tetrachloride was used for color development and the slides were counterstained with hematoxylin. Positive cells in images were measured with Image-Pro Plus software [1].
激酶實驗The inhibitory activity of YN968D1 against tyrosine kinases was determined using ELISA methodology described previously. Her-2, c-kit, and c-src were activated intracellular protein tyrosine kinases expressed by Bab-to-Bac Baculovirus Expression Vector System and purified by Ni-NTA spin columns. The optical density was measured at 490 nm using VERSAmax. The inhibitory activity was expressed as IC50, which was calculated from three independent experiments by the Logit method [1].
動物實驗The effects of YN968D1 on tumor growth were tested against various human tumors grown subcutaneously in BALB? cA nude mice. Tumor growth was initiated by subcutaneous inoculation of cells into mice. Tumors were allowed to establish and grow to 100–300 mm^3, at which time the mice were randomized into experimental groups. YN968D1 was administered once daily by oral gavage for the indicated periods. In combination treatment experiments, mice were administered YN968D1 alone by oral gavage; 5-FU, oxaliplatin, docetaxel and doxorubicin alone by intravenous injection; or YN968D1 in combination with each cytotoxic drug at the indicated dose and schedule. Tumor volume and body weight were monitored every other day or every 3 days, with the means indicated for groups of six (treated) or 12 (vehicle control) animals. Tumor volumes were determined by measuring the largest diameter (a) and its perpendicular (b) according to the formula (a ×b^2)? 2. The evaluation index for inhibition was the relative tumor growth ratio according to the equation: T?C (%) = mean increase of tumor volumes of treated groups?mean increase of tumor volumes of control groups ×100% [1].
體外活性體外酶活性實驗表明，Apatinib是一種比sunitinib更具選擇性的VEGFR-2抑制劑，其IC50分別為0.001 μM和0.005 μM。Apatinib還能有效抑制Ret, c-kit和c-src的活性，其IC50分別為0.013 μM, 0.429 μM和0.53 μM。在高達10 μM的濃度下，Apatinib對EGFR, Her-2或FGFR1沒有顯著影響。Apatinib輕微抑制由20% FBS刺激的HUVEC增殖（IC50: 23.4 μM），而對由20 ng/mL VEGF刺激的HUVEC增殖有顯著抑制作用（IC50: 0.17 μM）。在相同條件下，sunitinib的IC50值更低（分別為7.4 μM和0.034 μM）。1 μM Apatinib顯著抑制了FBS誘導的HUVEC遷移。在1 μM濃度下，sunitinib也能抑制HUVEC遷移。Apatinib顯著增強了在過表達ABCB1的KBv200、MCF-7/adr和HEK293/ABCB1細胞以及過表達ABCG2的S1-M1-80、MCF-7/FLV1000和HEK293/ABCG2-R2細胞中，ABCB1或ABCG2底物化合物的細胞毒性。與此相反，apatinib并未改變親本細胞和過表達ABCC1細胞中特定化合物的細胞毒性。Apatinib顯著增加了多藥抗性（MDR）細胞內(nèi)羅丹明123和多柔比星的積累。此外，apatinib還顯著抑制了ABCB1和ABCG2與[(125)I]碘芳基偶氮吡唑相的光親和標記，這種抑制作用是濃度依賴性的。Apatinib顯著增加了ABCB1和ABCG2的ATP酶活性。然而，在產(chǎn)生MDR逆轉(zhuǎn)的濃度下，apatinib并未顯著改變ABCB1或ABCG2的蛋白或mRNA表達水平，也未改變AKT和細胞外信號調(diào)節(jié)激酶1/2（ERK1/2）的磷酸化。
存儲條件Store at low temperature,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.85 mM), Sonication is recommended.
DMSO : 25 mg/mL (60.61 mM), Sonication is recommended.
關鍵字VEGFR2 | UT15 | UT 15 | Treprostinil Sodium | Treprostinil | RET | ProstaglandinReceptor | Prostaglandin Receptor | IP | Inhibitor | inhibit | EP3 | DP1 | cRET
相關產(chǎn)品Rutin | Lornoxicam | Ribociclib | Lenvatinib | p-Hydroxycinnamic acid | Rebamipide | Pazopanib | Nintedanib | Tranilast | Sorafenib | Nintedanib esylate | Taxifolin
相關庫抗癌上市藥物庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫 | 激酶抑制劑庫 | 臨床失敗化合物庫 | FDA 上市藥物庫 | GPCR靶點分子庫 | 免疫/炎癥分子化合物庫 | 膜蛋白靶向化合物庫 | 藥物功能重定位化合物庫 | FDA 上市激酶抑制劑庫 | 抗癌藥物庫
關鍵字： 曲前列尼爾鈉;UT-15;TargetMol

公司簡介

成立日期 2013-04-18 （14年） 注冊資本 589.8595萬人民幣
員工人數(shù) 100-500人 年營業(yè)額 ￥ 1億以上
主營行業(yè) 天然產(chǎn)物,生物化工,化學試劑,生物技術服務 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • TargetMol 中國（陶術生物）
VIP 1年
  • 公司成立：14年
  • 注冊資本：589.8595萬人民幣
  • 企業(yè)類型：股份有限公司(非上市、自然人投資或控股)
  • 主營產(chǎn)品：活性分子、生化試劑、天然產(chǎn)物、重組蛋白、抗體相關、試劑盒、藥物篩選化合物庫、技術服務
  • 公司地址：靜安區(qū)江場三路238號8樓
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