PLD6, Human, 重組蛋白 (His),PLD6 Protein, Human, Recombinant (His)

PLD6, Human, 重組蛋白 (His)|TMPH-01689|TargetMol

價格	￥16000
包裝	1mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2026-05-08

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產(chǎn)品詳情

中文名稱:PLD6, Human, 重組蛋白 (His)	英文名稱:PLD6 Protein, Human, Recombinant (His)
品牌: TargetMol	產(chǎn)地: 美國
保存條件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	產(chǎn)品類別: 抑制劑
種屬: Human	表達系統(tǒng): E. coli
蛋白長度: 1-252 aa	標簽: N-6xHis
貨號: T011\|TMPH-01689

Product Introduction

Bioactivity

名稱	PLD6 Protein, Human, Recombinant (His)
描述	Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission. Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology. Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis. Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation. Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation. The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA). MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs. Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner.
存儲條件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
關(guān)鍵字	PLD 6 \| MitoPLD

關(guān)鍵字： Protein zucchini homolog;PLD6;Phospholipase D6 (PLD6);Phosphatidylcholine-hydrolyzing phospholipase D6;Mitochondrial phospholipase (MitoPLD);Mitochondrial cardiolipin hydrolase;Choline phosphatase 6;TargetMol

公司簡介

成立日期	2013-04-18 （14年）	注冊資本	589.8595萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生物化工,化學(xué)試劑,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

TargetMol 中國（陶術(shù)生物）

VIP 1年

公司成立：14年
注冊資本：589.8595萬人民幣
企業(yè)類型：股份有限公司(非上市、自然人投資或控股)
主營產(chǎn)品：活性分子、生化試劑、天然產(chǎn)物、重組蛋白、抗體相關(guān)、試劑盒、藥物篩選化合物庫、技術(shù)服務(wù)
公司地址：靜安區(qū)江場三路238號8樓

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PLD6, Human, 重組蛋白 (His)|TMPH-01689|TargetMol相關(guān)廠家報價

產(chǎn)品名稱	價格		公司名稱	報價日期
重組Human DSG3 蛋白, C-His	￥1588	VIP2年	普健生物（武漢）科技有限公司	2026-06-09
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組蛋白H3(H3)重組蛋白	￥2600	VIP5年	上海博爾森生物科技有限公司	2026-06-11

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