SMARCA4, Human, 重組蛋白 (His),SMARCA4 Protein, Human, Recombinant (His)

SMARCA4, Human, 重組蛋白 (His)|TMPH-02217|TargetMol

價格	￥4650
包裝	200μg

最小起訂量	200μg
發(fā)貨地	上海
更新日期	2026-05-08

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產(chǎn)品詳情

中文名稱:SMARCA4, Human, 重組蛋白 (His)	英文名稱:SMARCA4 Protein, Human, Recombinant (His)
品牌: TargetMol	產(chǎn)地: 美國
保存條件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	純度規(guī)格: 90.00%
產(chǎn)品類別: 抑制劑
種屬: Human	表達系統(tǒng): P. pastoris (Yeast)
蛋白長度: 700-1246 aa	標簽: N-6xHis
貨號: T011\|TMPH-02217

Product Introduction

Bioactivity

名稱	SMARCA4 Protein, Human, Recombinant (His)
描述	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2. Binds to RNA in a promiscuous manner. Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities.
存儲條件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
關(guān)鍵字	SNF2-β \| SNF2β \| SNF2L 4 \| SNF2-b \| SMARCA 4 \| Protein BRG1 \| BRG 1 \| BA F190A

關(guān)鍵字： Transcription activator BRG1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4;SNF2L4;SNF2-beta;SNF2B;SMARCA4;Protein BRG-1;Protein brahma homolog 1;Mitotic growth and transcription activator;BRG1-associated factor 190A (BAF190A);BRG1;BAF190A;ATP-dependent helicase SMARCA4;TargetMol

公司簡介

成立日期	2013-04-18 （14年）	注冊資本	589.8595萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生物化工,化學(xué)試劑,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

TargetMol 中國（陶術(shù)生物）

VIP 1年

公司成立：14年
注冊資本：589.8595萬人民幣
企業(yè)類型：股份有限公司(非上市、自然人投資或控股)
主營產(chǎn)品：活性分子、生化試劑、天然產(chǎn)物、重組蛋白、抗體相關(guān)、試劑盒、藥物篩選化合物庫、技術(shù)服務(wù)
公司地址：靜安區(qū)江場三路238號8樓

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SMARCA4, Human, 重組蛋白 (His)|TMPH-02217|TargetMol相關(guān)廠家報價

產(chǎn)品名稱	價格		公司名稱	報價日期
重組Human DSG3 蛋白, C-His	￥1588	VIP2年	普健生物（武漢）科技有限公司	2026-06-02
Recombinant Human SMARCA4 Protein	￥1950	VIP4年	上海滬震實業(yè)有限公司	2026-06-05
重組蛋白	￥1500	VIP7年	愛必信（上海）生物科技有限公司	2026-05-21

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