BTK, Human, 重組蛋白 (His),BTK Protein, Human, Recombinant (His)

BTK, Human, 重組蛋白 (His)|TMPH-02271|TargetMol

價格	￥3850
包裝	50μg

最小起訂量	50μg
發(fā)貨地	上海
更新日期	2026-05-08

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產品詳情

中文名稱:BTK, Human, 重組蛋白 (His)	英文名稱:BTK Protein, Human, Recombinant (His)
品牌: TargetMol	產地: 美國
保存條件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	純度規(guī)格: 90.00%
產品類別: 抑制劑
種屬: Human	表達系統: Baculovirus Insect Cells
蛋白長度: 1-659 aa	標簽: N-10xHis
貨號: T011\|TMPH-02271

Product Introduction

Bioactivity

名稱	BTK Protein, Human, Recombinant (His)
描述	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
存儲條件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
關鍵字	Aγglobulinemia tyrosine kinase (ATK) \| AGMX 1 \| AGglobulinemia tyrosine kinase (ATK)

關鍵字： Tyrosine-protein kinase BTK;BTK;Bruton tyrosine kinase;BPK;B-cell progenitor kinase (BPK);ATK;AGMX1;Agammaglobulinemia tyrosine kinase (ATK);TargetMol

公司簡介

成立日期	2013-04-18 （14年）	注冊資本	589.8595萬人民幣
員工人數	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產物,生物化工,化學試劑,生物技術服務	經營模式	貿易,工廠,試劑,定制,服務

TargetMol 中國（陶術生物）

VIP 1年

公司成立：14年
注冊資本：589.8595萬人民幣
企業(yè)類型：股份有限公司(非上市、自然人投資或控股)
主營產品：活性分子、生化試劑、天然產物、重組蛋白、抗體相關、試劑盒、藥物篩選化合物庫、技術服務
公司地址：靜安區(qū)江場三路238號8樓

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BTK, Human, 重組蛋白 (His)|TMPH-02271|TargetMol相關廠家報價

產品名稱	價格		公司名稱	報價日期
重組人BTK蛋白, His Tag (active enzyme)	詢價	VIP3年	北京百普賽斯生物科技股份有限公司	2026-06-17
重組Human GIP 蛋白, N-His	￥1268.00	VIP2年	普健生物（武漢）科技有限公司	2026-06-18
布魯東氏酪氨酸激酶(Btk)重組蛋白	￥2856	VIP7年	上海澤葉生物科技有限公司	2026-06-18

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