JAK2, Human, 重組蛋白 (His),JAK2 Protein, Human, Recombinant (His)

JAK2, Human, 重組蛋白 (His)|TMPH-02274|TargetMol

價格	￥11700
包裝	1mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2026-05-09

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產(chǎn)品詳情

中文名稱:JAK2, Human, 重組蛋白 (His)	英文名稱:JAK2 Protein, Human, Recombinant (His)
品牌: TargetMol	產(chǎn)地: 美國
保存條件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	純度規(guī)格: 97.00%
產(chǎn)品類別: 抑制劑
重組: 是	種屬: Human
表達(dá)物種: Human	蛋白長度: 752-1132 aa
標(biāo)簽: N-6xHis	修飾: N-6xHis
UniProt ID: O60674	PubChem CID: O60674
緩沖液: Tris/PBS-based buffer	表達(dá)系統(tǒng): E. coli
貨號: T011\|TMPH-02274

Product Introduction

Bioactivity

名稱	JAK2 Protein, Human, Recombinant (His)
描述	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
存儲條件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
關(guān)鍵字	JAK-2 \| JAK 2

關(guān)鍵字： Tyrosine-protein kinase JAK2;Janus kinase 2 (JAK-2);JAK2;TargetMol

公司簡介

成立日期	2013-04-18 （14年）	注冊資本	589.8595萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生物化工,化學(xué)試劑,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

TargetMol 中國（陶術(shù)生物）

VIP 1年

公司成立：14年
注冊資本：589.8595萬人民幣
企業(yè)類型：股份有限公司(非上市、自然人投資或控股)
主營產(chǎn)品：活性分子、生化試劑、天然產(chǎn)物、重組蛋白、抗體相關(guān)、試劑盒、藥物篩選化合物庫、技術(shù)服務(wù)
公司地址：靜安區(qū)江場三路238號8樓

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JAK2, Human, 重組蛋白 (His)|TMPH-02274|TargetMol相關(guān)廠家報價

產(chǎn)品名稱	價格		公司名稱	報價日期
重組人JAK2蛋白	詢價	VIP4年	維百奧（北京）生物科技有限公司	2026-05-28
Recombinant Human JAK2, N-His	詢價	VIP4年	武漢佰樂博生物技術(shù)有限公司	2026-07-29
重組Human B2M 蛋白, C-His	￥1788	VIP2年	普健生物（武漢）科技有限公司	2026-07-29

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