Lck, Human, 重組蛋白 (His),Lck Protein, Human, Recombinant (His)

Lck, Human, 重組蛋白 (His)|TMPH-02275|TargetMol

價格	￥11700
包裝	1mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2026-05-09

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產(chǎn)品詳情

中文名稱:Lck, Human, 重組蛋白 (His)	英文名稱:Lck Protein, Human, Recombinant (His)
品牌: TargetMol	產(chǎn)地: 美國
保存條件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	純度規(guī)格: 90.00%
產(chǎn)品類別: 抑制劑
種屬: Human	表達系統(tǒng): E. coli
蛋白長度: 1-539 aa	標簽: N-6xHis
貨號: T011\|TMPH-02275

Product Introduction

Bioactivity

名稱	Lck Protein, Human, Recombinant (His)
描述	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2.
存儲條件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
關(guān)鍵字	Protein YT 16 \| LSK

關(guān)鍵字： Tyrosine-protein kinase Lck;T cell-specific protein-tyrosine kinase;Proto-oncogene Lck;Protein YT16;p56-LCK;Lymphocyte cell-specific protein-tyrosine kinase;Leukocyte C-terminal Src kinase (LSK);LCK;TargetMol

公司簡介

成立日期	2013-04-18 （14年）	注冊資本	589.8595萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生物化工,化學(xué)試劑,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

TargetMol 中國（陶術(shù)生物）

VIP 1年

公司成立：14年
注冊資本：589.8595萬人民幣
企業(yè)類型：股份有限公司(非上市、自然人投資或控股)
主營產(chǎn)品：活性分子、生化試劑、天然產(chǎn)物、重組蛋白、抗體相關(guān)、試劑盒、藥物篩選化合物庫、技術(shù)服務(wù)
公司地址：靜安區(qū)江場三路238號8樓

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Lck, Human, 重組蛋白 (His)|TMPH-02275|TargetMol相關(guān)廠家報價

產(chǎn)品名稱	價格		公司名稱	報價日期
重組人LCK蛋白	詢價	VIP4年	維百奧（北京）生物科技有限公司	2026-05-28
重組Human DSG3 蛋白, C-His	￥1588	VIP2年	普健生物（武漢）科技有限公司	2026-06-09
重組蛋白	￥1500	VIP7年	愛必信（上海）生物科技有限公司	2026-05-21

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