Product Name：Polymyxin B nonapeptide
CAS No.：86408-36-8；2220175-42-6
Synonyms：多粘菌素B九肽PMBN；sPMBN
Catalog No.：218P082
Brand：Typeptide Biotech（肽研生物）
Description：Polymyxin B nonapeptide是一條由9個(gè)氨基酸組成的陽(yáng)離子環(huán)肽，序列中含有5個(gè)Dab，其主要官能團(tuán)是氨基，是一種來(lái)自抗生素多粘菌素B的多肽。Polymyxin B nonapeptide能與革蘭氏陰性細(xì)菌的外膜相互作用，從而通過(guò)促進(jìn)疏水性擴(kuò)散來(lái)增加膜的滲透性。Polymyxin B nonapeptide毒性較小，缺乏殺菌活性，并保持其通過(guò)透化革蘭氏陰性菌的外膜使革蘭氏陰性菌對(duì)幾種抗生素敏感的能力。Polymyxin B nonapeptide是從多粘菌素 B 中通過(guò)蛋白水解去除其末端氨基?；鶜埢@得的環(huán)狀肽。
Polymyxin B nonapeptide is a cationic cyclic peptide composed of nine amino acids, containing five Dab residues, with its primary functional group being the amino group. It is a polypeptide derived from the antibiotic polymyxin B. Polymyxin B nonapeptide interacts with the outer membrane of Gram-negative bacteria, thereby increasing membrane permeability through the promotion of hydrophobic diffusion. With lower toxicity and lacking bactericidal activity, it retains the ability to sensitize Gram-negative bacteria to several antibiotics by permeabilizing their outer membrane. Polymyxin B nonapeptide is obtained from polymyxin B through proteolytic removal of its terminal aminoacyl residues, resulting in a cyclic peptide.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | T-Dab-Dab-Dab-d-F-L-Dab-Dab-T(Lactam: Dab3-Thr9) |
Sequence(3-letter code) | H-Thr-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr9) |
Peptide Structure | 
|
Molecular Formula | C43H74N14O11 |
Molecular Weight | 963.13 |
訂購(gòu)聯(lián)系方式：
南京肽研生物生物科技有限公司
手機(jī)號(hào)：19961912513(微信同號(hào))
QQ: 2178255659
郵箱：sales@typeptide.com
聯(lián)系人：顧經(jīng)理
申明：本產(chǎn)品僅供科研使用，不得用于人體。
關(guān)鍵字： 多粘菌素B九肽PMBN；sPMBN;Polymyxin B nonapept;86408-36-8;多肽;多肽合成;
肽研生物坐落于國(guó)家級(jí)新區(qū)南京江北新區(qū)新材料產(chǎn)業(yè)園，是一家專業(yè)從事多肽產(chǎn) 品的研發(fā)、生產(chǎn)和銷售以及多肽技術(shù)轉(zhuǎn)讓的高新技術(shù)企業(yè)。公司秉持“誠(chéng)信、嚴(yán) 謹(jǐn)、務(wù)實(shí)”的匠人精神，持續(xù)投入研發(fā)，不斷創(chuàng)新，致力于為科研工作者提供豐 富全面的多肽修飾類型和優(yōu)質(zhì)的產(chǎn)品。