Human IL-1 Rrp2 / IL-1 R6 Protein, His Tag

分子別名（Synonym）

IL-1 R6,IL-1 Rrp2,IL1RL2,IL-1RL2,IL1Rrp2,IL-1Rrp2,IL1RRP2,IL-36R

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human IL-1 Rrp2, His Tag (IL2-H52H6) is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Arg 335 (Accession # Q9HB29-1).

Predicted N-terminus: Asp 20

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 37.8 kDa. The protein migrates as 55-66 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介紹

白細(xì)胞介素-1受體家族（IL-1 R）至少包含11個(gè)成員，包括IL-1 RI（IL-1 R1）、IL-1 RII（IL-1 R2）、IL-1 RAcP（IL1 R3）、ST2（T1/IL-1 R4）、IL-18 Ra（IL-1 Rrp/IL-1 R5）、IL-1 Rrp2（IL-1 RL2/IL-1 R6）、IL-18 Rb（AcPL/IL-1 R7）、IL-1RAPL1（TIGIRR2/IL1 R8）和TIGIRR-1（IL-1 R9）。所有家族成員的胞外區(qū)均包含三個(gè)免疫球蛋白（Ig）樣結(jié)構(gòu)域。大多數(shù)成員還擁有一個(gè)胞內(nèi)TIR（Toll樣受體/IL-1受體信號轉(zhuǎn)導(dǎo)）結(jié)構(gòu)域，該結(jié)構(gòu)域在Toll樣受體家族中也高度保守。相關(guān)蛋白SIGIRR（含單個(gè)Ig結(jié)構(gòu)域的IL-1 R相關(guān)分子）和IL-18BP與其他成員不同，僅含有一個(gè)Ig結(jié)構(gòu)域。