Human IL-23A Protein, Fc Tag

分子別名（Synonym）

IL23A, IL-23, IL-23A, IL23P19, P19, SGRF

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human IL-23A Protein, Fc Tag (ILA-H525h) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (Accession # Q9NPF7).

Predicted N-terminus: Arg 20

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 45.1 kDa. The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method / rFC method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介紹

白細(xì)胞介素-23亞基α（IL-23 alpha）可與IL12B結(jié)合形成IL-23白細(xì)胞介素，這是一種異二聚體細(xì)胞因子，在先天免疫和適應(yīng)性免疫中發(fā)揮作用。IL-23可能與IL-17共同構(gòu)成外周組織對(duì)感染的急性反應(yīng)。IL-23與由IL12RB1和IL23R組成的異二聚體受體復(fù)合物結(jié)合，激活Jak-Stat信號(hào)級(jí)聯(lián)反應(yīng)，刺激記憶性T細(xì)胞而非初始T細(xì)胞，并促進(jìn)促炎性細(xì)胞因子的產(chǎn)生。IL-23可誘導(dǎo)自身免疫性炎癥，因此可能與自身免疫性炎癥性疾病有關(guān)，并且對(duì)腫瘤發(fā)生具有重要意義。