PE-Labeled Monoclonal Anti-C11D5.3 scFv Antibody, Mouse IgG1 (3G8C1) (0.03% Proclin)

抗體來源（Source）

Monoclonal Anti-C11D5.3 scFv Antibody, Mouse IgG1 (3G8C1) is a non-neutralizing antibody expressed from human HEK293 cells, which provides higher batch consistency and long term security of supply.

應(yīng)用（Application）

Flow Cytometry (Evaluation of Anti-BCMA (C11D5.3 scFv) CAR Expression).

克隆號(hào)（Clone）

3G8C1

種屬（Species）

Mouse

亞型（Isotype）

Mouse IgG1 | Mouse kappa

特異性（Specificity）

Specifically recognizes C11D5.3 derived CARs.

免疫原（Immunogen）

Recombinant C11D5.3 scFv derived from HEK293 cell

偶聯(lián)（Conjugate）

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

同型對(duì)照（Isotype Control）

The isotype control is sold separately; please refer to Cat. No. DNP-PM1 for product information.

推薦稀釋比（Recommended Dilution）

1:50

制劑（Formulation）

Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

Please contact us for customized product forms or formulations.

重構(gòu)方法（Reconstitution）

Please refer to the Certificate of Analysis (CoA) for specific instructions.

For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 24 months in lyophilized state;

-70°C for 12 months after reconstitution.

2-8 °C for 12 months after reconstitution.

背景介紹

C11D5.3 是一種靶向 BCMA 的 IgG1 小鼠單克隆抗體，而 BCMA 是多發(fā)性骨髓瘤和淋巴瘤免疫治療的靶點(diǎn)。C11D5.3 scFv 是 BCMA 特異性 CAR 中最常用的胞外結(jié)構(gòu)域組分。迄今為止，已報(bào)道的多項(xiàng) CART-BCMA 臨床試驗(yàn)均包含源自 C11D5.3 的抗 BCMA scFv，例如 FDA 批準(zhǔn)的 CAR 產(chǎn)品 Abecma。