化合物 Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA

價(jià)格	￥2320	￥9150	詢價(jià)
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2026-07-15

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產(chǎn)品詳情

中文名稱:化合物 Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA	英文名稱:Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA
品牌: TargetMol	產(chǎn)地: 美國(guó)
保存條件: Keep away from moisture, Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.	產(chǎn)品類別: 抑制劑
貨號(hào): T008\|T10251

Product Introduction

Bioactivity

名稱	Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA
描述	Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist.
動(dòng)物實(shí)驗(yàn)	Male Wistar rats (weight range 225-250 g at purchase) are used throughout the study. Animals receive a PVN application of ACTH Ab (2 μg/rat) or IgG (2 μg/rat); administration of either ACTH (1 nM/rat) or saline icv is performed 5 min later [2].
體外活性	ACTH 1-39 (100-400 nM) has no toxic effect on neurons, while ACTH provides protection from excitotoxic neuronal death induced by glutamate (100 μM), NMDA (1 mM), AMPA (50 μM), and kainate (25 μM). ACTH at 400 nM provides substantial protection in each case. ACTH at either 200 or 400 nM protects neurons from quinolinic acid (25 μM). There is also protection by ACTH from cell death induced by 2 μM H2O2, which gives rise to reactive oxygen species (ROS), with significantly more protection at 400 nM ACTH compared to 200 nM. ACTH gives modest protection against the rapid release of nitric oxide (NO) by NOC-12 but not slow release by NOC-18. ACTH (200 or 400 nM) protects neurons from cytotoxic effects of staurosporine (10-20 nM), a classic inducer of cell death via apoptosis. ACTH reduces cell death from 80% to 55% [1].
體內(nèi)活性	The icv injection of ACTH significantly reduces cumulative food intake over the observation period compared with the saline/IgG group. The injection of ACTH Ab into the PVN abolishes the anorexigenic effect of ACTH. Infusion icv of ACTH significantly decreases cumulative food intake in rats that receive α-MSH Ab into the PVN and ACTH icv, and food intake is as low as in the group treated with ACTH icv and IgG into the PVN. Injection of either ACTH Ab or α-MSH Ab into the PVN significantly increases cumulative food intake compared with IgG-treated animals [2].
存儲(chǔ)條件	Keep away from moisture, Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
關(guān)鍵字	Adrenocorticotropic Hormone (ACTH) , rat TFA \| Adrenocorticotropic Hormone (ACTH) (139), rat TFA \| Adrenocorticotropic Hormone (ACTH) (1 39), rat TFA \| ACTH TFA \| ACTH
相關(guān)產(chǎn)品	Undecylenoyl phenylalanine \| Tetracosactide acetate \| 4-Methyl-6-Methoxycoumarin \| BMS-470539 dihydrochloride \| Bremelanotide Acetate \| [D-Trp8]-γ-MSH acetate(321351-81-9 free base) \| ACTH (1-17) acetate \| Fenoprofen Calcium \| α-MSH acetate \| α-MSH \| (±)-Eriodictyol \| MCL0020

關(guān)鍵字： ACTH (1-39) (mouse, rat) TFA;TargetMol

公司簡(jiǎn)介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國(guó)家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （14年）	注冊(cè)資本	589.8595萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
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公司成立：14年
注冊(cè)資本：589.8595萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
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公司地址：上海市靜安區(qū)江場(chǎng)三路238號(hào)8樓

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