背景資料

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

應用類型

WB、E

免疫原

P56524

來源宿主

小鼠

反應性

可識別人等種屬來源樣本的HDAC4蛋白。

保存建議

該抗體2-8°C可保存6個月。長期保存請分裝后放于 -20°C ，避免反復凍融。