哈喹諾是氯化8-羥基喹啉的混合物,作為抗大腸桿菌和沙門氏菌的飼料添加劑,有效成分為5,7-二氯-8-羥基喹啉(57%-74%)、5-氯-8-羥基喹啉(23%-40%)和不超過(guò)4%的7-氯-8-羥基喹啉。
哈喹諾的抗菌機(jī)制是通過(guò)與鐵、銅和鋅等金屬離子螯合,阻斷酶合成。另外,哈喹諾直接作用在動(dòng)物腸胃平滑肌,通過(guò)降低腸胃蠕動(dòng)性,提高營(yíng)養(yǎng)吸收率,對(duì)患痢疾的牲畜,療效特別顯著。
國(guó)外大量實(shí)驗(yàn)證明,動(dòng)物對(duì)哈喹諾吸收很少,藥物殘留問(wèn)題可以忽略,甚至對(duì)產(chǎn)蛋期家禽也無(wú)停藥期要求,哈喹諾是非常安全的產(chǎn)品,是喹乙醇、卡巴多和喹烯酮的替代產(chǎn)品。
DESCIPTION
Halquinol is a controlled mixture of chlorhydroxyquinolines. The constituents act synergistically to enhance biological activity.
The antimicrobial effects of halquinol derives from its ability to chelate metal ions, particularly iron, copper and zinc. In bacteria, fungi and protozoa, essential trace elements are thus removed, and enzyme functioning ceases.
Additionally, halquinol acts directly on gastrointestinal smooth muscle to slow down peristaltic activity. Thus absorption of nutrients, particularly in animals suffering from diarrhoea, is enhanced, and performance criteria are improved markedly.
Since very little halquinol is absorbed, residues are not a concern and no withholding period is needed, even for laying birds. Halquinol acts entirely in the gut and systemic activity is not necessary. Halquinol is a very safe product.
SPEC.
CAS Registry number: [8067-69-4]
CAS name(s): 5,7-Dichloro-8-quinolinol mixt with 5-chloro-8-quinolinol and 7-chloro-8-quinolinol Additional name(s): chlorquinol ;
Appearance: a yellowish white to yellowish grey powder
Loss on drying: Max.0.5% Chloride: Max.700 ppm. Sulphate: Max.700 ppm
5-7 dichloroquinolin-8-ol: 57.0% to 75.0%
5 chloroquinolin-8-ol: 23.0% to 40.0%
7-Chloroquinolin-8-ol: < 4.0%
8-hydroxyquinoline: <0.5%
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