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Product name
CBS Polyclonal Antibody
Isotype
IgG
Form
Lyophilized or Liquid
Tested applications
WB,IF,ELISA,IHC
Species reactivity
Human,Mouse
Host Species
Rabbit
Purity
Affinity purification
Immunogen Information：
Immunogen
Recombinant protein of human CBS
Calculated molecular weight
60kDa/61kDa
Observed molecular weight?
61kDa
Swiss Prot
P35520
Gene ID (NCBI)
875
Alternative Names
HIP4
Application Notes：
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
1:500 - 1:2000
IF
1:50 - 1:200
IHC
1:50 - 1:500
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Western blot analysis of extracts of various cell lines, using CBS antibody.
Immunofluorescence analysis of U2OS cells using CBS antibody.
Background：
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.?
Storage：
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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