描述
Recombinant 2019-nCoV S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685 is expressed with a Fc tag at the C-terminus.
Accession: QHD43416.1
別名：S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
來(lái)源：Human Cells
分子量：102.2kDa AP Mol Mass: 130-140kDa, reducing conditions
形態(tài)：Supplied as a 0.2 μM filtered solution of PBS, pH 7.4
純化方法：Affinity purification chromatography.
純度：Greater than 90% as determined by reducing SDS-PAGE.
活性：The ED50 of 2019-nCoV S1 Protein-Fc is 0.85 ug/ml.
儲(chǔ)存/保存方法：Reconstituted protein solution should be stored at ≤ -20°C.
背景說(shuō)明
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
愛(ài)必信可提供蛋白定*務(wù)：
愛(ài)必信擁有經(jīng)驗(yàn)豐富的專(zhuān)業(yè)技術(shù)人員，服務(wù)內(nèi)容包括基因合成，密碼子優(yōu)化，表達(dá)載體設(shè)計(jì)，大規(guī)模細(xì)胞培養(yǎng)和發(fā)酵，蛋白質(zhì)純化和質(zhì)量控制測(cè)試。定制的重組蛋白產(chǎn)品100%穩(wěn)定可溶、上清液純化蛋白更接近天然結(jié)構(gòu)、低內(nèi)毒素控制、純度可按需定制，提供檢測(cè)報(bào)告。
愛(ài)必信重組蛋白
愛(ài)必信新冠狀病毒（n-Cov）相關(guān)蛋白，歡迎咨詢(xún)選購(gòu)！
abs04701
Recombinant (2019-nCoV) Nucleocapsid Protein(N-6his)
100ug
科研實(shí)驗(yàn)
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Recombinant 2019-nCoV S1 Protein (C-mFc)
50ug/500ug/1mg
科研實(shí)驗(yàn)
abs04703
Recombinant 2019-nCoV S1 Protein(Mammalian, non-tag)
50ug/500ug/1mg
科研實(shí)驗(yàn)
abs04704
Recombinant 2019-nCoV S1 Protein (C-Fc)
50ug/500ug/1mg
科研實(shí)驗(yàn)
abs04705
Recombinant 2019-nCoV S protein RBD Protein (C-mFc)
50ug/500ug/1mg
科研實(shí)驗(yàn)
abs04706
Recombinant 2019-nCoV S Protein RBD (C-6His)
50ug/500ug/1mg
科研實(shí)驗(yàn)
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Recombinant 2019-nCoV S Protein RBD-SD1 (C-mFC)
50ug/500ug/1mg
科研實(shí)驗(yàn)
關(guān)鍵字： 2019-nCoV S1蛋白; 新冠狀病毒蛋白
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