What Is Amphotericin B?

Cas Number: 1397-89-3

Molecular Formula: C47H73NO17

Molecular Weight: 924.1 g/mol

HS Code: 2941909000

It is a yellow to orange powder used as an antibiotic. It is insoluble in water but easily soluble in lipids. It is one of our competitive pharmaceutical ingredients with China GMP. It is a polyene antifungal antibiotic produced by Streptomyces nodosus.

It can bind to ergosterol to depolarize the membrane and alter cell membrane permeability. Important intracellular components will leak from cell to cause bacterial cell death. 

As a broad-spectrum an antifungal agent, it has activity against many fungal species. Common side effects include mild to moderate serum aminotransferase elevations and hyperbilirubinemia, but very rare to see acute drug induced liver injury caused by it.

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