Resatorvid, also known as TAK-242, is a cell-permeable inhibitor of TLR4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. Resatorvid binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Resatorvid provides neuroprotection in experimental traumatic brain injury: implication in the treatment of human brain injury.
Properties:
Density: 1.39
Boiling Point: 461.958ºC at 760 mmHg
Melting Point: 68-69ºC
Flash Point: 233.184ºC
Refractive Index:1.574
Vapor Pressure: 0mmHg at 25°C
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crene