己酮可可堿基本信息MSDS用途與合成方法己酮可可堿價格(試劑級)上下游產(chǎn)品信息專題中文名稱:己酮可可堿中文同義詞:己酮可可堿;已酮可可豆堿;已酮可可堿;已酮可可堿,1-(5-氧代己基)可可堿;己酮可可堿標準品;3,7-二氫-3,7-二甲基-1-(5-氧己基)-1H-嘌呤-2,6-二酮;1-(5-氧代己基)可可堿;PDE抑制劑(PENTOXIFYLLINE)英文名稱:Pentoxifylline英文同義詞:3,7-DIHYDRO-3,7-DIMETHYL-1-(5-OXOHEXYL)-1H-PURINE-2,6-DIONE;PENTOXIFYLLINE;PENTOXYFYLLINE;PENTOXYIFYLLINE;PENTOXYPHYLINE;PTX;TRENTAL;1-(5-Oxohexyl)-3,7-dimethylxanthineCAS號:6493-05-6分子式:C13H18N4O3分子量:278.31EINECS號:229-374-5相關類別:小分子抑制劑;嘧啶;醫(yī)藥原料藥;醫(yī)藥原料;細胞生物學試劑;心腦血管;AllInhibitors;Inhibitors;Intermediates&FineChemicals;Pharmaceuticals;CyclicNucleotiderelated;pentoxifyllineMol文件:6493-05-6.mol己酮可可堿性質(zhì)熔點98-100°C沸點421.13°C(roughestimate)密度1.1713(roughestimate)折射率1.6000(estimate)儲存條件StoreatRT溶解度H2O:≥43mg/mL酸度系數(shù)(pKa)0.50±0.70(Predicted)形態(tài)solid顏色white波長(λmax)276nm(lit.)Merck14,7136CAS數(shù)據(jù)庫6493-05-6(CASDataBaseReference)NIST化學物質(zhì)信息Pentoxifylline(6493-05-6)EPA化學物質(zhì)信息1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-(6493-05-6)己酮可可堿用途與合成方法化學性質(zhì)白色針狀結晶。熔點105℃。易溶于水、苯、乙醇、氯仿，微溶于乙醇。無臭，味苦。用途該品為血管擴張藥，能改善腦和四肢的血液循環(huán)。小鼠口服LD50為1385mg/kg。生產(chǎn)方法由1，3-溴氯丙烷與乙酰乙酸乙酯在80℃左右環(huán)合得到2-甲基-3-乙氧羰基-5，6-二氫吡喃，再將其開環(huán)、溴化生成1-溴-5-已酮，然后與可可堿鈉鹽縮合制成已酮可可堿。