new catalyst with high efficiency. It can improve the reaction of high steric hindrance, low reactive acidylation between alcohol and amine. Its activity is 104-6 times of pyridine. It can be used to improve yield in the reactions such as acidylation, alkylation, etherification, esterification and ester exchange of organic synthesis, drug synthesis, pesticide, medicine, dye, spice, high molecule chemistry and analysis chemistry.