α-Cyclodextrin (α-CD), a soluble dietary fiber derived from corn, marketed under the trade name FBCx?, has the potential to help individuals manage their weight and improve their lipid profiles.

Structure

In α-cyclodextrin, the six glucose subunits are linked end to end via α-1, 4 linkages. The result has the shape of a tapered cylinder, with six primary alcohols on one face and twelve secondary alcohol groups on the other. The exterior surface of cyclodextrins is somewhat hydrophilic whereas the interior core is hydrophobic.

Applications

Initial studies in healthy overweight and/or obese diabetic individuals found that, in those consuming a normal to high fat diet over a 4 or 12 week period, α-CD use was associated with weight loss or maintenance and a reduction in triglyceride (TG) and cholesterol levels in hyperlipidemic individuals. Furthermore, α-CD use was associated with the positive effects of increasing insulin and leptin sensitivities. To date, the immediate post-prandial glucose and lipid responses to a fat-containing meal have not been reported.^[1]

Materials/method

This double blinded placebo controlled cross-over trial examined the effect of 2 g of α-CD taken immediately following consumption of a commercially prepared high-fat breakfast meal on the acute postprandial responses in healthy adults.

Results: The coincidental consumption of α-CD with a fat-containing meal was associated with a significant reduction in postprandial TG responses over time when compared to placebo. When incremental area under the curve was calculated, the area under the curve associated with α-CD consumption was significantly smaller than the Placebo area (0.30±1.07 mmol/L/3 h vs. 0.98±0.88 mmol/L/3 h, p<0.05). There were no significant changes in glucose or cholesterol levels.

Conclusion

α-Cyclodextrin was shown to significantly lower acute postprandial blood triglyceride levels.

Reference

[1]Patricia A. Jarosz .“The Effect of α-Cyclodextrin on postprandial lipid and glycemic responses to a fat-containing meal.”Metabolism: clinical and experimental 62 10 (2013): Pages 1443-1447.