一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Dasatinib:Class, Uses, Advantages,Usage and Toxicity

Jul 30,2025

Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.

Dasatinib

Class

Cancer medicine

Mechanism of action

Dasatinib is a type of cancer growth blocker called a tyrosine kinase inhibitor Open a glossary item (TKI). It works by blocking particular proteins on cancer cells that encourage the cancer to grow. This can help shrink the cancer or stop it growing.

Uses

Dasatinib is indicated for the treatment of newly diagnosed adults with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase, as well as adults with chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including imatinib, and adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy. Dasatinib is also indicated for the treatment of pediatric patients 1 year of age and older with Ph+ CML in chronic phase or newly diagnosed Ph+ ALL in combination with chemotherapy.

Advantages

Unlike imatinib, another tyrosine kinase used for the treatment of CML and Ph-positive ALL, dasatinib inhibits the active and inactive conformations of the ABL kinase domain. Also, mutations in the kinase domain of BCR-ABL may lead to relapse during imatinib treatment. Since dasatinib does not interact with some of the residues involved in those mutations, the use of this drug represents a therapeutic alternative for patients with cancers that have developed imatinib-resistance. The use of dasatinib was first approved by the FDA in 2006.

Usage

Dasatinib comes as a tablet to take by mouth. It is usually taken once a day, in the morning or in the evening, with or without food. Take dasatinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dasatinib exactly as directed.

Toxicity

Overdose cases with dasatinib occurred in isolated cases during clinical studies. Patients that received 280 mg of dasatinib per day for 1 week developed severe myelosuppression and bleeding. Since dasatinib is associated with severe myelosuppression, patients that ingest more than the recommended dosage should be monitored closely for myelosuppression and receive appropriate supportive treatment.[1]

Acute overdose in animals was associated with cardiotoxicity. In rodents, ventricular necrosis and valvular/ventricular/atrial hemorrhage were detected at single doses higher than or equal to 100 mg/kg (600 mg/m2). In monkeys receiving single doses higher than or equal to 10 mg/kg (120 mg/m2), there was a tendency for increased systolic and diastolic blood pressure. In rats, the oral LD50 of dasatinib is 50-100 mg/kg, and in monkeys, it is 25-45 mg/kg.

References

[1]FDA Approved Drug Products: Sprycel (dasatinib) tablets for oral use (February 2023) .

  • Related articles
  • Related Qustion
See also
4

Sodium sulfite (SS) is a white, odourless, crystalline powder with a sulfurous taste that has reducing properties.....

Apr 22,2026Inorganic chemistry
4

Cinacalcet hydrochloride is the first active pharmaceutical ingredient approved by the US FDA for the treatment of secondary hyperparathyroidism.....

Jul 30,2025Biochemical Engineering

Dasatinib

302962-49-8

Dasatinib manufacturers

  • Dasatinib
  • 302962-49-8 Dasatinib
  • 2026-06-08
  • CAS:302962-49-8
  • Min. Order: 1g
  • Purity: 98%min
  • Supply Ability: 1000g
  • Dasatinib
  • 302962-49-8 Dasatinib
  • 2026-06-03
  • CAS:302962-49-8
  • Min. Order: 2KG
  • Purity: USP26, EP VI / GMP DMF
  • Supply Ability: 20tons
  • Dasatinib
  • 302962-49-8 Dasatinib
  • $5.00
  • 2026-05-28
  • CAS:302962-49-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10000kg

长沙县| 友谊县| 肃北| 鄂托克旗| 大余县| 平阳县| 三原县| 临沭县| 锡林郭勒盟| 谢通门县| 高台县| 三门县| 平遥县| 林州市| 河北区| 凤凰县| 体育| 乾安县| 玉田县| 迁西县| 长宁县| 华亭县| 饶河县| 广宗县| 卫辉市| 依兰县| 汨罗市| 明溪县| 贵港市| 定远县| 凯里市| 崇左市| 前郭尔| 高州市| 吉木乃县| 静宁县| 温宿县| 诏安县| 泰州市| 永济市| 永宁县|