How does N-Chlorosuccinimide work as chlorine source?
May 9，2026
N-Chlorosuccinimide (NCS) is a chlorinating and oxidizing agent
that is used as source for chlorine in radical reactions and various electrophilic additions. Mechanistic experiments implicate a reaction pathway that proceeds via a
single electron oxidation of NCS that amplifies the electrophilicity of
the chlorine atom.
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- The Efficacy and Applications of N-Chlorosuccinimide: A Comprehensive Insight Dec 3, 2024
N-Chlorosuccinimide (1-chloropyrrolidine-2,5-dione;NCS) was first synthesized in 1886 by the chlorination of succinimide with chlorinated lime.
- What is N-Chlorosuccinimide? Mar 25, 2021
N-Chlorosuccinimide (NCS) is a chlorinating and oxidizing reagent. It is also used as a mild oxidant. NCS is related to succinimide, but with NCl in place of NH. The N-Cl bond is highly reactive, and NCS functions as a source of "Cl+".
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May 9，2026Drugs
N-Chlorosuccinimide
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