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Microbes and Infection

Microbes and Infection

IF: 2.7
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Long non-coding RNA-XLOC_002383 enhances the inhibitory effects of THP-1 macrophages on M. avium and functions as a competing endogenous RNA by sponging miR-146a-5p to target TRAF6

Published:1 September 2023 DOI: 10.1016/j.micinf.2023.105175 PMID: 37392988
Rong Hu , Kearabetsoe Matseliso Molibeli , Lin Zhu , Hui Li , Cai Chen , Yang Wang , Dehui Xiong , Jing Liu , Lijun Tang

Abstract

The morbidity associated with infection by Mycobacterium avium (M.?avium), a type of non-tuberculous mycobacteria (NTM), has increased in recent years due to infections that are easily missed, and thus, difficult to diagnose and treat. Here, we reported that miR-146a-5p was highly expressed, and XLOC_002383 and TRAF6 were downregulated in a time- and MOI-dependent manner in THP-1 macrophages infected with M.?avium. In macrophages obtained from peripheral blood mononuclear cells, the expression levels of XLOC_002383 and TRAF6 were also decreased, and miR-146a-5p expression was increased following 24?h of infection with M.?avium. miR-146a-5p was a target of XLOC_002383 and TRAF6 mRNA was a target of miR-146a-5p, and XLOC_002383 regulated TRAF6 expression by adsorbing miR-146a-5p, and further increased IL-6, TNF-α, IL-1β and iNOS levels in THP-1 macrophages. The results of qPCR and CFU assays indicated that XLOC_002383 decreased the intracellular M.?avium loads. Overall, the present study demonstrated that XLOC_002383 may function as a competing endogenous RNA and interacts with miR-146a-5p to increase THP-1 macrophage inflammatory factors and microbicidal mediators iNOS. This enhanced the inhibitory effects of THP-1 macrophages on M.?avium, which improved the understanding of the pathogenesis and host defenses in the process of NTM infectious diseases.

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