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Virus research

Virus research

IF: 2.7
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Anthracyclines inhibit SARS-CoV-2 infection.

Published:1 September 2023 DOI: PMID: 37379907
Zhen Wang , Qinghua Pan , Ling Ma , Jianyuan Zhao , Fiona McIntosh , Zhenlong Liu , Shilei Ding , Rongtuan Lin , Shan Cen , Andrés Finzi , Chen Liang

Abstract

Vaccines and drugs are two effective medical interventions to mitigate SARS-CoV-2 infection. Three SARS-CoV-2 inhibitors, remdesivir, paxlovid, and molnupiravir, have been approved for treating COVID-19 patients, but more are needed, because each drug has its limitation of usage and SARS-CoV-2 constantly develops drug resistance mutations. In addition, SARS-CoV-2 drugs have the potential to be repurposed to inhibit new human coronaviruses, thus help to prepare for future coronavirus outbreaks. We have screened a library of microbial metabolites to discover new SARS-CoV-2 inhibitors. To facilitate this screening effort, we generated a recombinant SARS-CoV-2 Delta variant carrying the nano luciferase as a reporter for measuring viral infection. Six compounds were found to inhibit SARS-CoV-2 at the half maximal inhibitory concentration (IC50) below 1 μM, including the anthracycline drug aclarubicin that markedly reduced viral RNA-dependent RNA polymerase (RdRp)-mediated gene expression, whereas other anthracyclines inhibited SARS-CoV-2 by activating the expression of interferon and antiviral genes. As the most commonly prescribed anti-cancer drugs, anthracyclines hold the promise of becoming new SARS-CoV-2 inhibitors.

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Procduct Name CAS Molecular Formula Supplier Price
Paxlovid 2628280-40-8 C23H32F3N5O4 307 suppliers Inquiry
Paxlovid 2628280-40-8 C23H32F3N5O4 307 suppliers Inquiry

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