一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Pediatric Drugs >>article
Pediatric Drugs

Pediatric Drugs

IF: 3.39
Download PDF

Sodium Thiosulfate: Pediatric First Approval.

Published:1 March 2023 DOI: 10.1007/s40272-022-00550-x PMID: 36517667
Sohita Dhillon

Abstract

Sodium thiosulfate (Pedmark?) is a chemoprotectant/antioxidant developed by Fennec Pharmaceuticals (formerly Adherex Technologies) to reduce to risk of hearing loss associated with cisplatin. Sodium thiosulfate reduces the risk of ototoxicity by interacting directly with cisplatin to produce inactive platinum species, as well as by causing intracellular effects (such as increasing antioxidant glutathione levels and inhibition of oxidative stress) after entering the cells through the sodium sulfate cotransporter 2. In September 2022, sodium thiosulfate received its first approval in the USA for reducing the risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with localized, non-metastatic solid tumours. Sodium thiosulfate is under regulatory review in the EU for the prevention of ototoxicity induced by cisplatin chemotherapy in patients 1 month to < 18 years of age with localised, non-metastatic, solid tumours. This article summarizes the milestones in the development of sodium thiosulfate leading to this pediatric first approval for reducing the risk of ototoxicity associated with cisplatin in pediatric patients.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Sodium thiosulfate 7772-98-7 Na2O3S2 965 suppliers $5.00-$1650.00
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00

Similar articles

IF:4.1

Capmatinib: First Approval.

ACS Chemical Neuroscience Sohita Dhillon,etc Published: 1 July 2020
IF:13

Letermovir: First Global Approval.

Drugs Esther S Kim,etc Published: 1 January 2018
IF:1.4

Sodium thiosulfate: new hope for the treatment of calciphylaxis.

Seminars in Dialysis Melvin R Hayden, David J A Goldsmith,etc Published: 1 May 2010
深水埗区| 融水| 灵寿县| 马山县| 思茅市| 曲麻莱县| 延津县| 呼和浩特市| 子洲县| 万盛区| 稻城县| 新宾| 周至县| 仙桃市| 营山县| 磐石市| 洛宁县| 廉江市| 恩平市| 肇源县| 绥江县| 稻城县| 介休市| 汶上县| 兴城市| 景东| 东阳市| 元阳县| 白水县| 马鞍山市| 扬中市| 绥德县| 宜丰县| 连平县| 龙川县| 华阴市| 宣威市| 宁南县| 云安县| 马龙县| 巴马|