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Pediatric Drugs

Pediatric Drugs

IF: 3.39
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Sodium Thiosulfate: Pediatric First Approval.

Published:1 March 2023 DOI: 10.1007/s40272-022-00550-x PMID: 36517667
Sohita Dhillon

Abstract

Sodium thiosulfate (Pedmark?) is a chemoprotectant/antioxidant developed by Fennec Pharmaceuticals (formerly Adherex Technologies) to reduce to risk of hearing loss associated with cisplatin. Sodium thiosulfate reduces the risk of ototoxicity by interacting directly with cisplatin to produce inactive platinum species, as well as by causing intracellular effects (such as increasing antioxidant glutathione levels and inhibition of oxidative stress) after entering the cells through the sodium sulfate cotransporter 2. In September 2022, sodium thiosulfate received its first approval in the USA for reducing the risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with localized, non-metastatic solid tumours. Sodium thiosulfate is under regulatory review in the EU for the prevention of ototoxicity induced by cisplatin chemotherapy in patients 1 month to < 18 years of age with localised, non-metastatic, solid tumours. This article summarizes the milestones in the development of sodium thiosulfate leading to this pediatric first approval for reducing the risk of ototoxicity associated with cisplatin in pediatric patients.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Sodium thiosulfate 7772-98-7 Na2O3S2 965 suppliers $5.00-$1650.00
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00

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