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Heliyon

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GDF11 inhibits adipogenesis of human adipose-derived stromal cells through ALK5/KLF15/β-catenin/PPARγ cascade

Published:21 January 2023 DOI: 10.1016/j.heliyon.2023.e13088 PMID: 36755591
Shimin Lin,?Lishan Zhong,?Jingyi Chen,?Zibo Zhao,?Rongze Wang,?Yexuan Zhu,?Junwei Liu,?Yanting Wu,?Cuifang Ye,?Fujun Jin,?Zhe Ren

Abstract

Obesity is a metabolic disease characterized by excessive fat storage, and the adipogenic differentiation of adipose-derived stromal cells (ADSCs) is closely linked to its occurrence. Growth differentiation factor 11 (GDF11), a well-known molecule in the field of anti-aging, also has great potential in regulating stem cell differentiation. In this study, we found that GDF11 inhibited adipogenic differentiation of human ADSCs in vitro by activating the WNT/β-catenin and SMAD2/3 pathways while inhibiting the AKT pathway. Moreover, the transcription factor Kruppel-like factor 15 (KLF15) was discovered to be an important downstream factor for GDF11 in inhibiting adipogenesis via the WNT/β-catenin pathway. Furthermore, AlphaFold2 structure prediction and inhibitor-blocking experiments revealed that ALK5 is a functional receptor of GDF11. Collectively, we demonstrated that GDF11 is a potential target for inhibiting adipogenic differentiation and combating obesity.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 395 suppliers $10.00-$6135.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 395 suppliers $10.00-$6135.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 395 suppliers $10.00-$6135.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 395 suppliers $10.00-$6135.00
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